Our New Article in Pediatric Neuroimaging
Exciting new research alert! Our latest study together with the team of Prof. Mariam Aboian and the PNOC Foundation (Pacific Pediatric Neuro-oncology Consortium Foundation) compares 2D and volumetric analyses in assessing treatment response in paediatric gliomas with BRAF V600E mutation.
Response assessment in paediatric gliomas is crucial for treatment evaluation, but current methods may have limitations.
The authors, conducted manual volumetric segmentations and 2D measurements in 31 participants, analyzing 292 follow-up studies. Neuroradiologists evaluated responses using BT-RADS criteria and the tumor growth curves were described by a mechanistic model.
While both 2D and volumetric analyses performed well in classifying partial responders, there were differences in longitudinal trajectories, impacting the transition from partial response to stable disease.
Our findings underscore the importance of further studies to understand the implications of these differences on clinical decision-making and outcomes.
external page Link to the publication.
Kudos to all authors: Divya Ramakrishnan, Sarah Brüningk from our lab, Marc von Reppert, Fatima Memon, Nazanin Maleki, Sanjay Aneja, Anahita Fathi Kazerooni, Ali Nabavizadeh, MingDe Lin, Khaled Bousabarah, Annette Molinaro, Theodore Nicolaides, Micheal Prados, Sabine Mueller and Mariam Aboian.
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